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July 1995

Studies in Patients With Corticosteroid Contact Allergy: A Flawed Analysis of Structure-Function Relationships-Reply

Author Affiliations

Department of Chemistry University Louis Pasteur F-67091 Strasbourg, France Jacques Drieghe

Leuven, Belgium

Arch Dermatol. 1995;131(7):852. doi:10.1001/archderm.1995.01690190108028

We are, of course, fully aware of all requirements needed for antigen recognition by T-cell receptors, and we agree that the nature of the antigen is determined by many factors.1,2 We are also aware that the ''ideal'' study would be to model the entire major histocompatibility complex molecule containing the hapten-modified peptide and see how this modulates the shape of what will be recognized by the corresponding T-cell receptor, but Kalish probably knows that this is not yet technically possible. In our article, we simply tried to see if the presence of substituents on cycle D of corticosteroid molecules, all other aspects being equal, could help to explain the cross-reaction patterns observed in patients sensitive to corticosteroids. Therefore, we stated in our article that one of our hypotheses was that all of the corticosteroid molecules considered were interacting with proteins in a similar way. This is supported by what

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