FOR MANY years, students of the neurofibromatoses focused on the principle of neural crest origin of lesions of these disorders. It was as though characterizing them as neurocristopathies would reveal the keys to pathogenesis more quickly and more compellingly. On the other hand, these same students have learned not to be surprised by unexpected associations and correlations in neurofibromatosis type 1 (NF-1), whether at the clinical or molecular level. It turns out that the latter approach has been more fruitful. Associations that do not seem to fit at first have become more revealing as their basic biological and molecular mechanisms are now amenable to analysis. In this issue of the Archives, Zvulunov et al1 focus on one set of associations in NF-1 that has fascinated me since the late 1970s: NF-1 and its association with juvenile xanthogranuloma (JXG), juvenile chronic myelogenous leukemia (JCML), or both.
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Riccardi VM. Skin, Blood, Nerve Cells, and HeritabilityNew Lessons From Neurofibromatosis Type 1. Arch Dermatol. 1995;131(8):944. doi:10.1001/archderm.1995.01690200082015