Mycosis fungoides primarily localized to the palms and soles is rare and has been previously reported as cutaneous lymphoma in four patients or as Woringer-Kolopp disease in eight patients.
Four patients were initially diagnosed and treated unsuccessfully for various palmoplantar dermatitides until histopathologic findings revealed mycosis fungoides. Each case exhibited a clonal rearrangement of T-cell receptor gamma genes and immunohistochemical studies consonant with mycosis fungoides. All patients had limited skin involvement without evidence of extracutaneous involvement.
Mycosis fungoides palmaris et plantaris is an uncommon expression of mycosis fungoides that manifests primarily on the palms and soles and clinically may mimic various inflammatory palmoplantar dermatoses. A biopsy is recommended in the evaluation of recalcitrant palmoplantar dermatoses.(Arch Dermatol. 1995;131:1052-1056)
Resnik KS, Kantor GR, Lessin SR, Kadin ME, Chooback L, Cooper HS, Vonderheid EC. Mycosis Fungoides Palmaris et Plantaris. Arch Dermatol. 1995;131(9):1052-1056. doi:10.1001/archderm.1995.01690210082013