Herpes gestationis is a blistering disease associated with pregnancy that almost invariably recurs in subsequent pregnancies.1,2 Immunologic factors have been implicated in the pathogenesis of herpes gestationis, and women with HLA-DR3 and -DR4 antigens are most at risk.3,4 Uninvolved pregnancies have been described and were thought to occur in association with a change in paternity.3 It has been suggested that an uninvolved pregnancy may occur if the fetus has the HLA-DR antigens possessed by the mother.1 We describe a patient whose first pregnancy was complicated by herpes gestationis but whose second was not, despite constant paternity and nonmatching HLA-DR antigens between mother and child.
Report of a Case.
A 27-year-old woman presented during the 16th week of her first pregnancy with a 4-week history of a pruritic periumbilical rash. Her pregnancy was otherwise uncomplicated. At presentation, tense blisters arising on urticated erythema were seen on the
Ibbotson SH, Lawrence CM. An Uninvolved Pregnancy in a Patient After a Previous Episode of Herpes Gestationis. Arch Dermatol. 1995;131(9):1091-1092. doi:10.1001/archderm.1995.01690210123027