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September 1995

Vesiculobullous Eruption Associated With Chronic Lymphocytic Leukemia: Report of Two Cases

Author Affiliations

Department of Dermatology Hôpital Pasteur BP 69 06002 Nice Cedex, France; Nice; Limoges, France; Nice

Arch Dermatol. 1995;131(9):1092-1093. doi:10.1001/archderm.1995.01690210124029

Occurrence of bullous disease in patients with chronic lymphocytic leukemia (CLL) leads to a high suspicion of an autoimmune blistering disorder, especially bullous pemphigoid or paraneoplastic pemphigus. However, the possibility of a characteristic vesiculobullous eruption associated with CLL must be kept in mind.1,2 We report two cases of this rare entity extensively studied by immunohistology.

Report of Cases  Case 1. In 1978, a 70-year-old man was diagnosed with CLL and IgM monoclonal gammopathy. In 1982, he had a pruritic blistering eruption consisting of a few infiltrated erythematous plaques, with some of them covered with vesiculae. The coalescence of vesiculae resulted in large tense bullae, several centimeters in diameter (Figure 1). Each plaque was fixed and healed in 3 to 5 days, sometimes leaving hyperpigmentation but no scar or milia. No bullae occurred on normal skin or on the mucosa. The course of the cutaneous disease was characterized by spontaneous

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