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October 1995

Fetal Morbidity in Herpes Gestationis

Author Affiliations

Milwaukee, Wis Mario Lecha, MD Barcelona

Servicio de Dermatologia Hospital Clinic Villarroel 170 08036 Barcelona, Spain

Arch Dermatol. 1995;131(10):1209-1210. doi:10.1001/archderm.1995.01690220117027

Herpes gestationis (HG) is an uncommon autoimmune bullous disease that appears during pregnancy or in association with trophoblastic tumors. It is characterized by an intensely pruritic vesiculobullous eruption that develops during the later part of pregnancy or during the immediate postpartum period. Direct immunofluorescence reveals linear deposits of C3 along the basement membrane zone in all patients with active disease.1 Although it is generally accepted that HG in the mother is not associated with an increased fetal risk, there is a tendency for premature and small-for-gestationalage babies to occur. Only a few studies have specifically addressed this issue. We have studied all patients diagnosed with HG at our Department of Dermatology since direct immunofluorescence became available; the issue of fetal complications was examined.

Patients and Methods.  All patients with HG seen at the Hospital Clinic, Barcelona, Spain, between February 1972 and November 1994 were included and retrospectively studied. The

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