Lichen planus (LP) is a common inflammatory skin disease, accounting for approximately 1% of all diagnoses seen in patients seeking dermatologic care. In some patients, therapy remains difficult, and systemic application of glucocorticosteroids, cyclosporine, systemic photochemotherapy with psoralen plus UV-A (PUVA), and acitretin have been used with limited success.1 To circumvent the problems of oral PUVA therapy, methoxsalen (8-methoxypsoralen) in a dilute bathwater solution may be applied to the skin before UV-A.2 A PUVA-bath photochemotherapy regimen has been shown to be an elegant alternative in the treatment of psoria- sis.2,3 We describe our first four patients with LP who received PUVA-bath photochemotherapy.
Patients and Methods.
Four patients (age range, 42 to 76 years) with histopathologically proven LP received PUVA-bath photochemotherapy (Table). All had a history of LP for 14 to 24 months and had received topical or systemic glucocorticosteroids, oral PUVA (one patient), and acitretin (one patient),
Kerscher M, Volkenandt M, Lehmann P, Plewig G, Röcken M. PUVA-Bath Photochemotherapy of Lichen Planus. Arch Dermatol. 1995;131(10):1210-1211. doi:10.1001/archderm.1995.01690220118028