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October 1995

Toxic Epidermal Necrolysis in Singapore, 1989 Through 1993: Incidence and Antecedent Drug Exposure

Author Affiliations

Department of Medicine Division of Dermatology National University of Singapore Lower Kent Ridge Road Singapore 1128

Arch Dermatol. 1995;131(10):1212-1213. doi:10.1001/archderm.1995.01690220120030

Before 1990, the incidence of toxic epidermal necrolysis (TEN) was largely undetermined. Since then, there have been published figures on the incidence of TEN in the United States,1 France,2 Germany,3 and Italy,4 but no figures have been published for a country in Asia. These figures have estimated the incidence to be 0.5 per million per year in the United States among persons using standard outpatient regimens. In the general population in Europe, the incidence is estimated to be 0.9 to 1.3 persons per million per year; 90% to 95% of such cases are believed to be caused by drug therapy.

The present study is an estimate of the incidence of drug-induced TEN in Singapore from 1989 through 1993.

Methods.  The total number of citizens and permanent residents in the 5-year period from 1989 through 1993 form the population base. All known cases of TEN from eight

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