I read with interest the article by Schreiner et al1 in the February 1995 issue of the Archives. They studied 58 skin specimens that included 13 basal cell carcinomas (BCCs), 10 squamous cell carcinoma (SCCs), and 14 malignant melanoma (MMs). Along with the results of other studies, the results of this article indicated that the number of Langerhans' cells (LCs) over BCCs, SCCs, and MMs were significantly lower than in normal skin.
In 1987 and 1989, we reported three studies with 42 BCCs,2 26 SCCs,3 and 19 MMs.4 We also used vertical sections of specimens and the identification was done with OKT6 (anti-CDla) and OKT-Dr(anti-HLA Dr, Ortho Diagnostics, Ravitan, NJ) with immunofluorescence. We found only a few LCs in the tumors, but an increased number of LCs in the epidermis above superficial BCCs. In SCCs, with more keratinization we found an increased number of LCs in
Valcuende-Cavero F. Langerhan's Cells in Skin Tumors. Arch Dermatol. 1995;131(12):1463. doi:10.1001/archderm.1995.01690240129025