Periungual fibroma is a diagnostic criterion of tuberous sclerosis (TS), with generally no consideration given to the number of fibromas or their location.1-3 Recently, Roach et al4 and Kwiakowski and Short5 stated that periungual fibromas are a significant criterion of TS if there are many fibromas. However, clinical studies confirming this assertion are lacking. Therefore, we examined whether the usual tests performed to rule out TS are necessary in patients presenting with a periungual fibroma. For editorial comment see page 1460
Patients and Methods.
Seven consecutive patients, 30 to 53 years of age, were seen between 1989 and 1993 for solitary periungual fibroma. All tumors were excised and examined histologically. A thorough evaluation was performed in each case, including extensive inquiry of personal or familial events suggestive of TS, physical examination (including Wood's light), and laboratory investigations to detect the occult signs of TS. Furthermore, we reviewed
Zeller J, Friedmann D, Clerici T, Revuz J. The Significance of a Single Periungual Fibroma: Report of Seven Cases. Arch Dermatol. 1995;131(12):1465-1466. doi:10.1001/archderm.1995.01690240131031