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Article
January 1996

Hepatitis C Virus Infection and Porphyria Cutanea Tarda in Australasia

Author Affiliations

Department of Dermatology Waikato Hospital New Zealand

Arch Dermatol. 1996;132(1):91. doi:10.1001/archderm.1996.03890250105021
Abstract

In the last 2 years, there has been interest in the relationship between hepatitis C virus (HCV) infection and porphyria cutanea tarda (PCT). Accordingly, we were concerned with identifying any of our patients with PCT who may have HCV infection so as to offer counseling and treatment. Patients known to suffer from PCT were contacted through outpatient appointments or by correspondence and were asked to provide a serum specimen for HCV analysis and measurement of alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, protein, and albumin concentrations, and for a complete blood cell count. Of the 25 patients traced, none were found to have evidence of active HCV infection. This included six members of a single family with familial PCT. Serum samples were screened for antibody to HCV using an enzyme-linked immunosorbent assay. Test results were positive in one patient, but amplification of HCV RNA followed by Southern blotting and hybridizing

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