Background and Design:
Lymphomatoid papulosis (LyP) and cutaneous Hodgkin's disease share many clinical, histopathologic, and immunohistochemical features. Epstein-Barr virus (EBV) has been implicated in the pathogenesis of several lymphoid malignancies, including Hodgkin's disease. Given the similarities between LyP and Hodgkin's disease, we asked if EBV could be detected in lesions of LyP. We examined 31 specimens of LyP that were obtained from 24 patients for evidence of EBV by in situ hybridization to EBER1 transcripts and for immunohistochemistry of viral latent membrane protein 1 (LMP1).
In no instance was there any evidence of EBV gene products by either in situ hybridization or immunohisto-chemistry.
The absence of EBV in LyP suggests that this virus is not operative in the pathogenesis of LyP. Furthermore, it suggests that LyP and Hodgkin's disease may not share the same molecular mechanisms despite their phenotypic similarities.(Arch Dermatol. 1996;132:279-282)
Sangüeza OP, Galloway J, Eagan PA, Braziel RM, Gulley ML. Absence of Epstein-Barr Virus in Lymphomatoid PapulosisAn Immunohistochemical and In Situ Hybridization Study. Arch Dermatol. 1996;132(3):279-282. doi:10.1001/archderm.1996.03890270051007