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Article
May 1996

A Primary Cutaneous Non-T, Non-B CD4+, CD56+ Lymphoma

Author Affiliations

From the Departments of Dermatology (Drs Dummer, Häffner, Burg, and Ms Potoczna) and Pathology (Dr Zimmermann), University of Zürich (Switzerland) Medical School. Dr Gilardi is in private practice in Locarno, Switzerland.

Arch Dermatol. 1996;132(5):550-553. doi:10.1001/archderm.1996.03890290084011
Abstract

Background:  Cutaneous lymphomas are heterogeneous clonal lymphoproliferative disorders originating from B or T lymphocytes.

Observation:  We describe a patient with a unique primary cutaneous lymphoma characterized by a bruiselike aspect of the skin lesions, a CD4+, CD43+, CD56+, CD2-, CD3-, CD8-, T-cell receptor-negative phenotype of the medium-sized to large lymphoid tumor cells and an undetermined genotype (T-cell receptor β and immunoglobulin heavy chain in germline configuration, no clonal T-cell receptor γ population as detected after analysis with polymerase chain reaction combined with denaturing gradient gel electrophoresis) and fast relapse after radiotherapy.

Conclusions:  This non-B, non-T cutaneous lymphoma cannot be classified by any current lymphoma classification. It seems to represent a new disease entity with peculiar clinical, histologic, and molecular features.Arch Dermatol. 1996;132:550-553)

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