Numerous drugs have been reported to produce fixed drug eruptions (FDE).1 These drugs were first described by Brocq in 1894 and include analgesic, anti-infectious, cardiovascular, gastrointestinal, neurologic, psychopharmaceutical, and antineoplastic drugs. Benzodiazepines, although widely prescribed throughout the world, account for only a small minority of published cases of FDE. 1 Oxazepam has been rarely associated with diffuse exanthems and urticaria but, to our knowledge, no previous case of FDE has been reported with this drug.
Report of a Case.
An 85-year-old woman was admitted in September 1995 with a diffuse macular, erythematous, pruriginous eruption that appeared 3 months earlier. The eruption was clinically typical of an FDE. The patient was treated with low-dose aspirin and digoxin for paroxysmal atrial fibrillation. A history of oxazepam intake for insomnia was also noted. Histologic examination of a biopsy specimen from the lesion showed numerous keratinocyte necroses and lymphocytic dermal infiltrates. Results of
Krischer J, Prins C, Ruffieux P, Kondo-Oestreicher M, Saurat J. Extensive Fixed Drug Eruption Induced by Oxazepam. Arch Dermatol. 1996;132(6):718. doi:10.1001/archderm.1996.03890300148033