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September 1996

Interleukin-10 Is a Predominant Cytokine in Atopic Dermatitis

Author Affiliations

Clinical Department Diabetes Research Institute Heinrich-Heine-University of Düsseldorf Auf'm Hennekamp 65 40225 Düsseldorf Germany

Manfred Hüther


Schwelm, Germany


Arch Dermatol. 1996;132(9):1133-1134. doi:10.1001/archderm.1996.03890330149035

Immune regulation in atopic dermatitis (AD) is biased to a T-helper 2-dominated immune response resulting in the production of IgE, eosinophilia, and impaired delayed-type hypersensitivity reactions. Allergen-specific T-cell clones from patients with AD selected through prolonged in vitro culture show a typical T-helper 2 cytokine pattern secreting interleukin (IL)-4 and IL-5.1 However, analysis of general immune reactivity to mitogens in freshly isolated peripheral blood mononuclear cells did not consistently show a bias toward IL-4 production in patients with AD.2-4 We observed a significant bias toward IL-10 in whole-blood cultures from patients with AD, while the production of IL-4, as well as of the T-helper 1 cytokines interferon-γ (IFN-γ) and tumor necrosis factor α (TNF-α), was normal. Recently, a similar bias toward IL-10 but not IL-4 was found in AD skin lesions.5

Patients and Methods.  Thirteen patients with AD (3 men and 10 women) aged between 22 and 38 years without any drug treatment were studied, and 28 age-matched healthy persons served as controls. Heparinized peripheral venous blood was placed in 48-hole

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