REPORT OF A CASE
A 42-year-old woman who suffered for more than 2 years from disseminated localized scleroderma (LS) (Figure 1) markedly improved during treatment with psoralen with UV-A (PUVA) bath photochemotherapy with 8-methoxy-psoralen (8-MOP).1 The 8-MOP was applied to the skin during a warm water bath, which was immediately followed by UV-A exposure. Clinical, histological, and ultrasound indications of LS (Figure 2) regressed almost completely during PUVA bath photochemotherapy in this and 2 other patients, 1 with disseminated LS and 1 with contractures caused by linear LS of the dorsal aspects of the left thigh and entire left leg.1
No single therapy produces uniform disease remission in LS.2-6 A safe and effective therapy associated with the least potential complications is required.
Since clinical regression of sclerosis was confirmed by ultrasound and histological evaluations, we considered PUVA bath photochemotherapy a promising novel therapeutic approach
Kerscher M, Meurer M, Sander C, Volkenandt M, Lehmann P, Plewig G, Röcken M. PUVA Bath Photochemotherapy for Localized SclerodermaEvaluation of 17 Consecutive Patients. Arch Dermatol. 1996;132(11):1280-1282. doi:10.1001/archderm.1996.03890350014001