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November 1996

PUVA Bath Photochemotherapy for Localized SclerodermaEvaluation of 17 Consecutive Patients

Author Affiliations

Ludwig-Maximilians-Universität München, Munich, Germany

Dr Kerscher is now with the University of Bonn and Dr Lehmann is now with the University of Düsseldorf.

Arch Dermatol. 1996;132(11):1280-1282. doi:10.1001/archderm.1996.03890350014001

REPORT OF A CASE  A 42-year-old woman who suffered for more than 2 years from disseminated localized scleroderma (LS) (Figure 1) markedly improved during treatment with psoralen with UV-A (PUVA) bath photochemotherapy with 8-methoxy-psoralen (8-MOP).1 The 8-MOP was applied to the skin during a warm water bath, which was immediately followed by UV-A exposure. Clinical, histological, and ultrasound indications of LS (Figure 2) regressed almost completely during PUVA bath photochemotherapy in this and 2 other patients, 1 with disseminated LS and 1 with contractures caused by linear LS of the dorsal aspects of the left thigh and entire left leg.1

THERAPEUTIC CHALLENGE  No single therapy produces uniform disease remission in LS.2-6 A safe and effective therapy associated with the least potential complications is required.

SOLUTION  Since clinical regression of sclerosis was confirmed by ultrasound and histological evaluations, we considered PUVA bath photochemotherapy a promising novel therapeutic approach

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