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Article
December 1996

Diffuse Cutaneous MastocytosisTreatment With Oral Psoralen Plus UV-A

Author Affiliations

Geisinger Medical Center, Danville, Pa

Arch Dermatol. 1996;132(12):1429-1430. doi:10.1001/archderm.1996.03890360013002
Abstract

REPORT OF A CASE  A 4-month-old female infant presented with 1 month of blisters on her chin and temple that progressed to diffuse blistering. Blisters formed if the infant was scratched or rubbed (Figure 1). She had numerous bullae and erosions on her trunk and extremities and her skin had a diffuse doughy texture. The patient had no wheezing or gastrointestinal symptoms and was otherwise healthy. The family history was negative for any dermatologic, gastrointestinal, or hematologic diseases. One month of antibiotic therapy resulted in no change and bacterial blister culture results were negative. Biopsy samples showed a dense dermal infiltrate of mast cells consistent with mastocytosis. A Leder stain accentuated the mast cell granules.Evaluation for systemic involvement, including bone marrow biopsy and aspiration, computed tomography of the abdomen, a bone scan, and an upper gastrointestinal tract series with small-bowel follow-through, produced normal results.Initial treatment consisted of topical

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