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December 1996

Augmented Betamethasone: Efficacy in Psoriasis With Different Dosing Frequencies

Author Affiliations

Department of Dermatology Institute of Medical Sciences Banaras Hindu University Varanasi 221005, India

Arch Dermatol. 1996;132(12):1525-1526. doi:10.1001/archderm.1996.03890360119032

Like most of the topical corticosteroids, augmented (optimized 0.05%) betamethasone dipropionate (ABD) is recommended to be used twice daily,1 despite a lack of evidence to establish this as the optimum schedule.2 Because of the depot effect of topical corticosteroids,3 it may be possible to reduce their dosing frequency without affecting the efficacy. We have recently concluded that there is no difference in the efficacy of ABD in the treatment of plaque psoriasis with twice daily vs once daily application.4 In the present study, the efficacy of ABD was evaluated with even lower dosing frequencies, ie, alternate day, once in 72 hours, and weekly.

Patients and Methods.  Patients with plaque psoriasis of more than 1 month and with at least 4 stable equivalent lesions (indicator lesions, 2 on each ventral forearm) were enrolled. Exclusion criteria included drug-induced psoriasis, psoriasis requiring systemic therapy, any treatment in the previous

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