Using representational DNA analysis, previously unknown herpesviruslike DNA sequences (designated human herpesvirus 8 [HHV-8]) were discovered in Kaposi sarcoma (KS) lesions from patients with acquired immunodeficiency syndrome (AIDS).1 We recently summarized this rapidly advancing field dealing with HHV-8 and immunodeficiency-associated diseases, such as KS.2 Despite an earlier suggestion that HHV-8 DNA sequences were present in proliferating skin lesions other than KS in transplant recipients, other studies3-5 have found no evidence of HHV-8 DNA sequences in cutaneous epithelial neoplasms from either immunosuppressed or immunocompetent patients. To continue exploring the possible role of HHV-8 in other non-KS skin tumors, we examined multiple dermatofibromas in the clinical setting from patients with an autoimmune disease: systemic lupus erythematosus (SLE).
In contrast to the common occurrence of 1 to 2 dermatofibromas in otherwise healthy individuals, dozens and even hundreds of dermatofibromas can erupt on the skin of patients with altered immunological
Foreman K, Bonish B, Nickoloff B. Absence of Human Herpesvirus 8 DNA Sequences in Patients With Immunosuppression-Associated Dermatofibromas. Arch Dermatol. 1997;133(1):108-109. doi:10.1001/archderm.1997.03890370120026