The use of isotretinoin for the treatment of acne has increased over the past 10 years because of its effectiveness and the limited and generally reversible adverse effects associated with it. Although not mentioned in comprehensive reviews of the adverse effects of isotretinoin therapy, hypertrophic scar and keloid formation, both spontaneous and associated with cutaneous injury, are potential risks.1 Dermatologists and cosmetic surgeons have noted an increased incidence of keloid and hypertrophic scar formation with dermabrasion, excisions, and argon laser treatment.2,3 These therapies all share local disruption in the structure of collagen in the skin.
The pulsed dye laser (585 nm, 450 microseconds) has been proven safe and effective treatment for various small-diameter vascular processes, such as capillary vascular malformations, hemangiomas, telangiectases, pyogenic granulomas, and angiomas. Using the principles of selective photothermolysis, the pulsed dye laser can deliver high-intensity energy to a target vessel with little to
Bernestein LJ, Geronemus RG. Keloid Formation With the 585-nm Pulsed Dye Laser During Isotretinoin Treatment. Arch Dermatol. 1997;133(1):111-112. doi:10.1001/archderm.1997.03890370123029