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January 1997

Imported Dengue—United States, 1995

Arch Dermatol. 1997;133(1):121-122. doi:10.1001/archderm.1997.03890370133037

DENGUE IS an acute disease caused by any of four mosquito-transmitted virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4) and characterized by the sudden onset of fever, headache, myalgias, rash, nausea, and vomiting. The disease is endemic in most tropical areas of the world and can occur in U.S. residents returning from travel to such areas. This report summarizes information about imported dengue among U.S. residents during 1995 and documents a substantially increased incidence of dengue in the Caribbean, Central America, and Mexico.

Serum samples from 441 persons who had suspected dengue with onset in 1995 were submitted to CDC for diagnostic testing from 31 states and the District of Columbia. Of these, 79 (18%) cases from 21 states were serologically or virologically diagnosed as dengue by isolation of dengue virus, detection of anti-dengue immunoglobulin M, single high titers of immunoglobulin G antibodies in acute serum samples, or a fourfold or

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