We read with great interest the article by Glass and Solomon1 in a recent issue of the Archives on the use of cimetidine to treat common warts. The authors report excellent results with this therapy. We conducted a similar study, but our results differed from those of Glass and Solomon and showed lower cure rates.2 We report a different experience with the use of cimetidine to treat common warts and emphasize the need for placebo-controlled studies to assess the efficacy of this treatment.
We performed a prospective, randomized control trial with 40 patients. They all had more than 3 warts, present for at least 6 months, and had failed to respond to different treatments. Most of the patients were children (62% were younger than 15 years). In addition to the exclusion criteria used by Glass and Solomon, healthy men were not included in our study because of the
Sáenz-Santamaría MC, Gilaberte Y. Cimetidine and Warts. Arch Dermatol. 1997;133(4):530. doi:10.1001/archderm.1997.03890400136026