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April 1997

Cimetidine and Warts-Reply

Author Affiliations

250 W 57th St, Suite 12312 New York, NY 10019

Arch Dermatol. 1997;133(4):530-531. doi:10.1001/archderm.1997.03890400136027

We read with interest the letter of Sáenz-Santamaría and Gilaberte regarding our study of cimetidine hydrochloride in the treatment of recalcitrant warts in adults. The authors present data in which the efficacy of cimetidine appears to be considerably lower than that presented in our study. The majority of patients in their study were children and dosages used ranged from 20 to 40 mg/kg per day. Despite this broad range, 30% of patients did show a partial to complete response to cimetidine therapy and no disease progression was reported while patients were taking the medication. Our experience is that 35 to 40 mg/kg per day is required to achieve a clinical response. In addition, none of the patients in our study experienced any adverse effects or abnormal laboratory findings while taking these high dosages. A significant number of nonresponders in our study were taking the lower dosage of medication. Similar results

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