April 1997

Rare Presence of Human Herpesvirus 8 in Skin Tumors From Patients With Psoriasis Treated With Oral Psoralen Plus UV-A

Author Affiliations

Department of Dermatology University of Graz Auenbruggerplatz 8 A-8036 Graz, Austria


Arch Dermatol. 1997;133(4):538-539. doi:10.1001/archderm.1997.03890400144034

Kaposi sarcoma—associated herpeslike virus, or human herpesvirus 8 (HHV-8) has been found in classic, endemic African, and Kaposi sarcomas (KSs) related to the acquired immunodeficiency syndrome (AIDS).1-3 The virus has also been found in non-KS tumors of immunocompromised patients, including body cavity lymphomas in patients with AIDS,4 a primary cerebral B-cell lymphoma in a patient uninfected with the human immunodeficiency virus given long-term steroid therapy,5 and various benign and malignant epithelial skin tumors of transplant recipients undergoing immunosuppressive therapy.6 Oral psoralen plus UV-A (PUVA) photochemotherapy, which is widely used to treat psoriasis, is also known to cause cutaneous malignancies (mainly squamous cell carcinomas)7 and to be associated with immune system suppression.8 To determine if HHV-8 is also associated with PUVA-induced (ie, iatrogenic) immune system suppression and tumorigenesis in patients with skin disease, we looked for HHV-8 in premalignant and malignant skin lesions of patients

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