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July 1997

Sequences of Human Herpesvirus 8 Are Not Detected in Various Non-Kaposi Sarcoma Vascular Lesions

Author Affiliations

Policlinique de Dermatologie Hôpital St-Louis 1 Ave C1 Vellefaux 75010 Paris, France


Villejuif, France


Arch Dermatol. 1997;133(7):919-920. doi:10.1001/archderm.1997.03890430141027

A new virus, human herpesvirus 8 (HHV-8), has recently been associated with Kaposi sarcoma (KS), body cavity—based lymphoma, and Castleman disease.1 Using polymerase chain reaction (PCR) with the KS330233 primers, HHV-8 sequences were detected in an angiosarcoma specimen from a 63-year-old woman who was seronegative for the human immunodeficiency virus,2 in 4 cases of angiolymphoid hyperplasia and eosinophilia,3 in 7 of 24 angiosarcomas, and in 1 of 20 hemangiomas.4 Other authors5,6 have failed to demonstrate evidence of HHV-8 in various vascular lesions from Japanese or Chinese patients, including hemangiomas, hemangiopericytomas, pyogenic granulomas, and cutaneous or visceral angiosarcomas. However, a lack of test sensitivity could account for these negative results since they were obtained from parraffin-embedded tissues using a simple PCR. Taking into account these controversial findings, our aim was to obtain further data on the presence of HHV-8 in benign or malignant non-KS vascular

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