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Article
July 1997

Skin Barrier: Principles of Percutaneous Absorption

Author Affiliations

Redwood City, Calif

 

by Hans Schaefer and Thomas E. Redelmeier, 310 pp, Basel, Switzerland, S Karger AG, 1996.

Arch Dermatol. 1997;133(7):924. doi:10.1001/archderm.1997.03890430146031

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Abstract

Schaefer and Redelmeier have done an outstanding job on their book Skin Barrier: Principles of Percutaneous Absorption. Their combined expertise in skin barrier function and lipid physical chemistry has produced a text with relevance to the medical community, pharmaceutical research and development community, and those interested in the fundamentals of molecular transport through the stratum corneum.

The book is divided into 6 main sections dealing with skin structure and function, stratum corneum composition and structure, membrane diffusion theory and its application to the stratum corneum, and 3 sections on the prediction and measurement of percutaneous absorption.

The introductory sections on skin and stratum corneum structure and composition are a thorough update of information found in previous books. These chapters form a strong biological, biochemical, and ultrastructural framework. What is truly unique about this book, however, can be found by patient readers who continue on to the later sections.

The chapter

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