We thank Drago and Reborafor their interest in our work. They state that the hypothesis drawn from our data, which suggests that there could be a link between human herpesvirus (HHV) 8 detection in peripheral blood mononuclear cells and clinical staging of Kaposi sarcoma, is contrary to all that is known of HHV biological behavior. They rely on data concerning 2 HHVs, HHV-6 and HHV-7, which, to our knowledge, have not been consistently associated with any human neoplastic disease and, as far as HHV-7 is concerned, to any human disease. The statement by Drago and Rebora regarding our hypothesis seems rather hazardous considering that various data suggest alink between HHV viremia in the peripheral blood mononuclear cells and either the severity or the duration of the disease. For instance, the presence of a larger amount of mononuclear cells infected with HHV-6 correlates with a longer rash phase in infants with exanthema subitum.
Lebbé C, Agbalika F. Role of Human Herpesvirus 8 in Kaposi Sarcoma Unclear-Reply. Arch Dermatol. 1997;133(8):1050-1051. doi:10.1001/archderm.1997.03890440134026