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September 1997

Immunology of Human Melanoma

Author Affiliations

Boston, Mass

Arch Dermatol. 1997;133(9):1177. doi:10.1001/archderm.1997.03890450129025

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


Enthusiasm for immunotherapy as a treatment modality for melanoma is building momentum, and rightly so. Immunology of Human Melanoma is a timely text for spectators and beginner players in the field of cancer immunology. Advances in antigen processing, elucidation of the effector mechanisms of cytolytic T cells, identification of cytokines that augment immunity, and, most important, the cloning of tumor antigens have provided a foundation to develop rational therapies. The identification of melanoma antigen 1 by Boon and colleagues set the stage for subsequent immune-based therapies for melanoma and possibly for all cancers.

This volume represents a collection of 21 chapters grouped into 4 large sections: adhesion molecules and cytokines, HLA antigens and accessory molecules, tumor antigen recognition, and immunotherapy. The book's structure is clearly designed for the basic immunologist rather than the melanoma clinician. The contributors are well-recognized authorities and represent the community of melanoma experts from Europe, North

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