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Off-Center Fold
August 2007

Erythematous Papules and Plaques Involving the Groin and Scrotum—Diagnosis

Author Affiliations


Arch Dermatol. 2007;143(8):1067-1072. doi:10.1001/archderm.143.8.1067-f

Histologic examination of the biopsy specimen revealed proliferating nests and cords of balloon-shaped cells infiltrating into the dermis, with a narrow, uninvolved grenz zone beneath the epidermis. The individual cells contained hyperchromatic, atypical nuclei with frequent mitosis and abundant cytoplasm. These histologic findings were consistent with primary transitional cell urothelial carcinoma. Magnetic resonance imaging also revealed diffuse metastatic disease to the brain. Our patient received hospice care and palliative radiation therapy for his metastatic disease. A topical corticosteroid cream (0.025% triamcinolone) was prescribed for symptomatic relief of the intermittent pruritus and pain that were associated with the skin lesions.

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