MICHAEL E.MINGMD, MSCECARRIE ANN R.CUSACKMDSENAIT W.DYSONMDJACQUELINE M.JUNKINS-HOPKINSMDVINCENTLIUMDKARLA S.ROSENMANMD
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Histopathologic examination of the biopsy specimen demonstrated superficial crust and hemorrhage, with an associated dermal infiltrate of cells containing abundant eosinophilic cytoplasm and a reniform or indented nucleus, characteristic of Langerhans cells (Figure 4, arrows), admixed with eosinophils. On immunohistochemical analysis, the cells were positive for S100 protein and CD1a antigen, findings that were consistent with a definitive diagnosis of LCH.
Petechial and Red-Brown Papular Lesions in a 2-Year-Old Girl—Diagnosis. Arch Dermatol. 2007;143(8):1067-1072. doi:10.1001/archderm.143.8.1068