An 89-year-old woman with liver metastases from a gastrointestinal stromal tumor (GIST) was treated with imatinib mesylate, initial dose of 400 mg/d. Three months later, the liver tumors decreased. Again 3 months later, a computed tomographic (CT) scan revealed 3 intrapulmonary lesions that radiologically resembled an infectious complication or metastases of the GIST. Owing to the age of the patient and continuous decline of her physical status, a lung biopsy was excluded. The progressing pulmonary tumors were clinically interpreted as metastases of the GIST, and therefore imatinib mesylate treatment was continued.
Yazdi AS, Metzler G, Weyrauch S, Berneburg M, Bitzer M, Müller-Hermelink H, Röcken M. Lymphomatoid Granulomatosis Induced by Imatinib-Treatment. Arch Dermatol. 2007;143(9):1209-1226. doi:10.1001/archderm.143.9.1222