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September 2007

Lymphomatoid Granulomatosis Induced by Imatinib-Treatment

Arch Dermatol. 2007;143(9):1209-1226. doi:10.1001/archderm.143.9.1222

An 89-year-old woman with liver metastases from a gastrointestinal stromal tumor (GIST) was treated with imatinib mesylate, initial dose of 400 mg/d. Three months later, the liver tumors decreased. Again 3 months later, a computed tomographic (CT) scan revealed 3 intrapulmonary lesions that radiologically resembled an infectious complication or metastases of the GIST. Owing to the age of the patient and continuous decline of her physical status, a lung biopsy was excluded. The progressing pulmonary tumors were clinically interpreted as metastases of the GIST, and therefore imatinib mesylate treatment was continued.

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