Tacrolimus is a macrolide antibiotic produced by Streptomyces tsukubaensis and with strong T-specific immunosuppressant activity. Primarily used for treatment of atopic dermatitis, it has been used to treat other inflammatory and immunologic skin disorders, including vitiligo, with encouraging results.1 Focal hypertrichosis has been reported during topical tacrolimus therapy for childhood vitiligo,2 but acne does not seem to be a frequently reported adverse effect.
Bakos L, Bakos RM. Focal Acne During Topical Tacrolimus Therapy for Vitiligo. Arch Dermatol. 2007;143(9):1209-1226. doi:10.1001/archderm.143.9.1223