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October 2007

Subcutaneous Nodule and Diffuse Lymphadenopathy in a 6-Month-Old Boy From Africa—Diagnosis

Author Affiliations
 

MICHAEL E.MINGMD, MSCECARRIE ANN R.CUSACKMDSENAIT W.DYSONMDJACQUELINE M.JUNKINS-HOPKINSMDVINCENTLIUMDKARLA S.ROSENMANMD

Arch Dermatol. 2007;143(10):1323-1328. doi:10.1001/archderm.143.10.1323-e

The cutaneous papule and the lymph node showed the same pathologic features. The hematoxylin-eosin–stained sections demonstrated the presence of a granulomatous infiltrate with multinucleated Langerhans-type giant cells and calcified spherules resembling psammoma bodies or Schaumann bodies (Figure 2 and Figure 3). Fite-stained sections demonstratedthe presence of a few acid-fast bacilli (Figure 4). A mycobacterial culture of the lymph node was negative. On polymerase chain reaction testing, the lymph node was positive for Mycobacterium bovis BCG. A purified protein D test result was positive.

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