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November 2007

Fractional Photothermolysis: A Novel Treatment for Disseminated Superficial Actinic Porokeratosis

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Copyright 2007 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2007

Arch Dermatol. 2007;143(11):1447-1462. doi:10.1001/archderm.143.11.1450

Disseminated superficial actinic porokeratosis (DSAP) occurs diffusely in sun-exposed areas, notably the legs and forearms. The exposed nature of the lesions can cause emotional distress among patients. Additionally, these lesions present a risk of transformation into invasive squamous cell carcinoma. Treatments for DSAP have had mixed results, especially for extensive lesions. We report 2 cases of DSAP responding to treatment with fractional photothermolysis.

A 47-year-old woman with Fitzpatrick skin type II presented with multiple, pruritic, scattered, red-brown macules with peripheral scale covering her lower extremities, clinically consistent with DSAP. Biopsy findings confirmed the diagnosis. Previous treatments included cryotherapy, topical diclofenac, tazarotene, and intralesional triamcinolone.

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