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November 2007

Bleomycin-Induced “Flagellate Dermatitis”

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Copyright 2007 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2007

Arch Dermatol. 2007;143(11):1447-1462. doi:10.1001/archderm.143.11.1461

A 45-year-old woman with stage IA nodular sclerosing Hodgkin lymphoma began a regimen of doxorubicin, bleomycin, vinblastine, and dacarbazine chemotherapy. Seventy-two hours later, she developed intensely itchy, erythematous, linear lesions affecting the arms, back, neck, occipital scalp, and hands. She was prescribed clobetasone propionate ointment, 0.05%, twice daily (Dermovate; GlaxoSmithKline, Brentford, Middlesex, England) because the pruritic eruption was suggestive clinically of a lichenoid dermatitis, and the rash subsided following the completion of the first course of chemotherapy.

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