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November 2007

Recurrent Calcified Cutaneous Nodule of the Perianal Region—Diagnosis

Author Affiliations
 

MICHAEL E.MINGMD, MSCECARRIE ANN R.CUSACKMDSENAIT W.DYSONMDJACQUELINE M.JUNKINS-HOPKINSMDVINCENTLIUMDKARLA S.ROSENMANMD

Arch Dermatol. 2007;143(11):1441-1446. doi:10.1001/archderm.143.11.1442-g

The biopsy specimen showed a diffuse, predominantly histiocytic infiltrate mixed with rare neutrophils and lymphocytes. The histiocytes had distinct cellular borders and granular cytoplasm that stained with periodic-acid–Schiff and were immunopositive for CD68. Many of the histiocytes contained concentric intracytoplasmic, basophilic, calcified spherules characteristic of Michaelis-Gutmann bodies (Figure 3, arrows)

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