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March> 1, 2008

Recessive Palmoplantar KeratodermasA Fertile Biological Hunting Ground

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Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2008

Arch Dermatol. 2008;144(3):384-385. doi:10.1001/archderm.144.3.384

In this issue of the Archives, Kabashima et al1 describe a Japanese teenager with a hyperhidrotic, erythrodermic, transgredient nonsyndromic palmoplantar keratoderma (PPK). In finding phenotypic similarities with other patients formerly described in the Japanese dermatology literature, Kabashima and colleagues convincingly argue that their patient probably represents the recessive type of keratoderma first described by Nagashima et al2 in 1977. Autosomal recessive inheritance was speculated in view of the lack of parental transmission and the occurrence of the disease in multiple affected siblings.

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