March> 1, 2008

Amelanotic Melanoma in a Patient With Rothmund-Thomson Syndrome

Author Affiliations

Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2008

Arch Dermatol. 2008;144(3):416-417. doi:10.1001/archderm.144.3.416

A 23-year-old white woman with Rothmund-Thomson syndrome (RTS) presented with a 1-month history of a 4-mm hyperkeratotic, skin-colored papule on the cutaneous surface of her right upper lip (Figure 1). A shave biopsy specimen showed a malignant melanoma that extended to the base of the specimen (1.20 mm) (Figure 2). Wide local excision with 1-cm margins was performed, and the depth of the melanoma was determined to be 2.44 mm. The sentinel lymph node biopsy findings were negative for malignancy. Findings of a metastatic workup, including positron emission tomography, computed tomography of her chest, abdomen and pelvis, and bone scan with technetium Tc 99m hydroxymethylene diphosphonate, were negative.