A 20-year-old woman presented with stage IIIB (T4bN1aM0) melanoma. In November 2004, she had begun treatment with subcutaneous injections of interferon alfa-2b, 3 MU, 3 times per week. The treatment was well tolerated with only minor injection site reactions and acute urticaria during the first doses. In April 2006, she developed symmetrical depressed plaques on both thighs (Figure 1), and interferon alfa-2b therapy was interrupted. There was no history of local trauma. A biopsy specimen showed a perilobular lymphocytic infiltrate with lobular atrophy (Figure 2).
Vallés L, González M, Polo I, Enguita AB, Vanaclocha F, Ortiz-Romero PL. Lipoatrophy Associated With Interferon Alfa Adjuvant Therapy for Melanoma. Arch Dermatol. 2009;145(1):98-99. doi:10.1001/archdermatol.2008.531