More than 25 years of accumulating evidence strongly implicates the immune system in the pathogenesis of psoriasis, including both acquired immunity (T cells) and innate host defense (macrophages, antigen-presenting cells, and keratinocytes). Psoriasis also has a strong genetic component, but the identity of the genes involved has largely remained obscure. In a study recently published in Nature Genetics,1 these 2 themes of psoriasis—genetics and immunology—come together in a coherent and clinically relevant way.
Nair RP, Ding J, Duffin KC, Helms C, Voorhees JJ, Krueger GG, Bowcock AM, Abeçasis GR, Elder JT. Psoriasis Bench to BedsideGenetics Meets Immunology. Arch Dermatol. 2009;145(4):462-464. doi:10.1001/archdermatol.2009.73