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April 2009

Cole Disease: Guttate Hypopigmentation and Punctate Palmoplantar Keratoderma

Arch Dermatol. 2009;145(4):495-497. doi:10.1001/archdermatol.2009.54

Cole disease is an autosomal dominant genodermatosis characterized by guttate hypopigmentation and palmoplantar keratoses. Initially described in the Archives in 1976,1 an additional affected family has subsequently been identified.2 We herein describe a child with Cole disease, drawing attention to findings that distinguish it from other genodermatoses that feature pigmentary anomalies and punctate keratoderma.

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