JAMES M.GRICHNIKMD, PhD
We describe 4 patients with known mutations in the PTEN gene (OMIM 158350) to illustrate the use of dermoscopy and the histologic appearance of palmar lesions in Cowden syndrome. The first case involved a 52-year-old woman with multiple small, skin-colored, smooth palmar keratotic macules (Figure 1); cases 2 and 3 involved 2 sisters, aged 31 and 32 years, with multiple small palmar keratotic macules (Figure 2 and Figure 3); and case 4 involved a 55-year-old woman with multiple small keratotic macules on her fingers (Figure 4A) and multiple white papules on the mucous membranes (Figure 4B).
Jarrett R, Walker L, Soilleux E, Bowling J. Dermoscopy of Cowden Syndrome. Arch Dermatol. 2009;145(4):508-509. doi:10.1001/archdermatol.2009.22