Among the challenges of the protean disorder leukocytoclastic vasculitis is discovering its cause. The occurrence of leukocytoclastic vasculitis in response to activity is an uncommonly recognized association. We highlight the association of physical activity with cutaneous small-vessel vasculitis and suggest that activity also be considered as a cause of leukocytoclastic vasculitis.
A 24-year-old woman had a 3-year history of recurrent outbreaks of purpuric edematous plaques on the forearms, lower legs, and dorsal surfaces of the feet. Some plaques that had areas of central and peripheral clearing imparting crescent and gyrate shapes also had a peripheral rim of pallor (Figure 1). A histologic specimen is shown in Figure 2. Direct immunofluorescence demonstrated fibrin in vessel walls, and no immunoreactivity for IgG, IgA, IgM, or C3 was noted.
Garg A, Goldberg D. Relapsing Leukocytoclastic Vasculitis Triggered by Activity in a Young Woman. Arch Dermatol. 2009;145(5):601-602. doi:10.1001/archdermatol.2009.66