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Evidence-Based Dermatology: Research Commentary
June 2009

Adalimumab vs Methotrexate for the Treatment of Chronic Plaque Psoriasis—Reply

Author Affiliations
 

MICHAELBIGBYMD

 

DAMIANOABENIMD, MPHROSAMARIACORONADSc, MDURBÀGONZÁLEZMD, PhDABRAR A.QURESHIMD, MPHHYWELWILLIAMSMSc, PhD, FRCP

Arch Dermatol. 2009;145(6):706. doi:10.1001/archdermatol.2009.706

In reply

The thorough review and thoughtful comments are greatly appreciated. The payoff for having “resisted the temptation of doing just a placebo-controlled study” was that this study provided the most robust scientific results to date on the relative clinical benefits and risks of traditional systemic vs biological therapies and may thereby help shape the evolving treatment algorithm for psoriasis. Including a placebo control, requiring patients to have been naïve to methotrexate and anti-TNF therapy, and using a double-dummy design and separate efficacy and safety assessors made the study onerous to conduct but also eliminated or minimized potential biases. In response to Batchelor et al, we offer the following:

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