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Off-Center Fold
July 2009

Generalized Ulcerated Nodules in a Patient With Human Immunodeficiency Virus Infection—Diagnosis

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Arch Dermatol. 2009;145(7):829-834. doi:10.1001/archdermatol.2009.142-b

Histopathologic examination of the specimen showed an ulcerated papule with crust overlying a follicle. In the superficial and deep dermis, a dense periadnexal and perivascular cell infiltrate extending up to the dermoepidermal junction was observed (Figure 2). This infiltrate was predominantly composed of lymphocytes, histiocytes, scanty neutrophils, and plasma cells. Vessels in the dermis appeared congested and showed prominent endothelial cells (Figure 3). Spirochetes were demonstrated by Whartin-Starry stain (Figure 3, inset).

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