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October 2009

Asymptomatic Red Plaque on the Leg of a 7-Year-Old Girl—Diagnosis

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Arch Dermatol. 2009;145(10):1183-1188. doi:10.1001/archdermatol.2009.214-b

Hematoxylin-eosin staining of the biopsy specimens showed a diffuse, dense infiltrate in the upper dermis and a patchy, perivascular and periadnexal infiltrate in the lower dermis (Figure 2) composed of predominantly plasmacytoid cells (Figure 3). In situ hybridization revealed a κ light-chain–restricted population. Immunohistochemical stains were diffusely positive for CD79a and IgG and essentially negative for CD20, IgD, IgM, and IgA. A fluorescence polymerase chain reaction assay was positive for a clonal immunoglobulin heavy-chain gene rearrangement. Cultures of punch biopsy specimens were negative for bacteria, fungi, and mycobacteria.

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