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November 2009

A Rapidly Growing Lesion on the Lip—Diagnosis

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Arch Dermatol. 2009;145(11):1325-1330. doi:10.1001/archdermatol.2009.252-b

Findings from the lesional biopsy specimen revealed numerous inflammatory granulomas composed of histiocytes and giant cells containing yeastlike formations with multiple gemmulation—diagnostic of PCM—best seen with Grocot stain (Figure 4). Mycological examination confirmed the diagnosis with identification of the Paracoccidioides brasiliensis. Treatment with sulfamethoxazole and trimethoprim was started. Notable reduction of the lesion was obtained within 2 months of specific treatment, and the treatment is to continue for at least 2 years.

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