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Correspondence
December 2009

A Case of Lichen Sclerosus of the Scalp Associated With Autoantibodies to Extracellular Matrix Protein 1

Arch Dermatol. 2009;145(12):1458-1460. doi:10.1001/archdermatol.2009.313

Lichen sclerosus (LS) is a chronic inflammatory skin disease of unknown cause with a predilection for the anogenital area. Recent investigation has identified serum IgG autoantibodies specific to extracellular matrix protein 1 (ECM1) in 74% of patients with anogenital LS1; however, the rationale for humoral autoimmunity to ECM1 in the extragenital disease has been enigmatic. Herein, we describe the first case to our knowledge of extragenital LS associated with IgG autoantibodies to ECM1.

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