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The Best of the Best
January 2013

Top-Accessed Article: Primary Generalized and Localized Hypertrichosis in Children

JAMA Dermatol. 2013;149(1):42. doi:10.1001/jamadermatol.2013.747

Vashi RA, Mancini AJ, Paller AS. Primary generalized and localized hypertrichosis in children. Arch Dermatol. 2001;137(7):877-884.

“Primary Generalized and Localized Hypertrichosis in Children” remains an essential reference for physicians caring for children with primary hypertrichosis. In this article, Vashi and colleagues present a framework for recognizing and classifying primary hypertrichosis and defining patterns and associations. They highlight the limited treatment options and the significance of the psychosocial burden of these disfiguring conditions. As the authors noted, and to this day, the management of hypertrichosis in the pediatric population remains a challenge. Most of the currently available removal options are temporary, uncomfortable, and/or costly. Moreover, there are few data regarding their use in pediatric patients. Over the last decade, there have been significant discoveries relating to the identification of genes expressed in the hair follicle, and knowledge has been gained from families with rare hair disorders.1 Understanding the potential genetic causes of primary hypertrichosis may provide insight into hair follicle development and normal hair growth, which could lead to improved treatments for this rare disorder.

From October 2010 to August 2011, this article was accessed 1997 times on the Archives of Dermatology website.

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Contact Dr Garzon at the Department of Dermatology, Columbia University, 161 Fort Washington Ave, New York, NY 10032 (

Shimomura Y, Christiano AM. Biology and genetics of hair.  Annu Rev Genomics Hum Genet. 2010;11:109-132PubMedArticle