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Comment & Response
January 04, 2017

Incorrect Figure Alignment and Error in Figure Legend

Author Affiliations
  • 1Departments of Dermatology, Genetics, and Pathology, Yale University School of Medicine
JAMA Dermatol. Published online January 4, 2017. doi:10.1001/jamadermatol.2016.5267

To the Editor We are writing to correct errors in our previously published report, titled “Symptomatic Congenital Hemangioma and Congenital Hemangiomatosis Associated With a Somatic Activating Mutation in GNA11.1 In Figure 3B, which depicts the region of the p.Q209P somatic mutation in our tumor sample viewed using the Integrated Genome Viewer software, the horizontal gray bars representing individual exome reads were off center. This was the result of our graphics software misaligning the reads with the histogram above it, causing a strange step-off to be seen. Herein, we provide a correctly aligned Figure.

Figure.
Histogram Showing Mosaic Mutation Expression in Tumoral Tissue but Not Saliva
Histogram Showing Mosaic Mutation Expression in Tumoral Tissue but Not Saliva

Integrated Genome Viewer software was used to visualize exome sequencing reads. The histograms on the top of each panel represent the total coverage for individual base, with each horizontal gray line representing an individual 74–base pair paired read. Vertical black bars designate the c.A626, p.Q209 locus. Of 37 reads covering this region in tissue (top), 11 (30%) were nonreference calls. Blue highlighted rows represent the 11 nonreference reads. A total of 60 reads obtained in saliva DNA indicate 100% reference reads, suggesting no mutation in the germline (bottom).

In addition, the original Figure 3B caption incorrectly stated that there were 26 nonreference calls (C) and 11 reference calls (A), for a ratio of 70% nonreference. Instead, the numbers should be flipped: there are 26 reference calls and 11 nonreference calls, for a nonreference ratio of 30%. This has also been corrected in the Figure legend. None of the study’s conclusions are affected by these errors or their corrections.

We have requested that the article2 be corrected online. We sincerely apologize for any confusion this may have caused the readers and editors of the journal.

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Article Information

Corresponding Author: Keith Choate, MD, PhD, 333 Cedar St, New Haven, CT 06520 (Keith.choate@yale.edu).

Published Online: January 4, 2017. doi:10.1001/jamadermatol.2016.5267

Conflict of Interest Disclosures: None reported.

References
1.
Funk  T, Lim  Y, Kulungowski  AM,  et al.  Symptomatic congenital hemangioma and congenital hemangiomatosis associated with a somatic activating mutation in GNA11JAMA Dermatol. 2016;152(9):1015-1020.
PubMedArticle
2.
 Errors in figure and caption  [published online January 4, 2017]. JAMA Dermatol. doi:10.1001/jamadermatol.2016.5390
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